Incidence and genetics of Legg-Perthes disease (osteochondritis deformans) in British Columbia: evidence of polygenic determination.
نویسندگان
چکیده
Legg-Perthes disease (osteochondritis deformans) is an aseptic necrosis of the capital femoral epiphysis. The clinical and radiographic features of Legg-Perthes disease have been well documented (Goff, Shutkin, and Hersey, 1954; Kemp and Boldero, 1966) but apart from Molloy and MacMahon's Massachusetts study (1966) few epidemiologic investigations have been reported. A genetic component to the disease has been suggested by many authors (Goff et al, 1954; Goff, 1962) but the extent of familial occurrence and mode of inheritance have not been defined. The objectives of this study were twofold: firstly, to determine the incidence of Legg-Perthes in the Province of British Columbia, Canada, by identifying all children in whom the diagnosis was made for the first time during the period 1952-67 inclusive; secondly, to analyse for possible genetic factors.
منابع مشابه
Evolution in diagnosis and treatment of Legg-Calve-Perthes disease
Legg-Calvé-Perthes disease (LCPD) is an idiopathic osteonecrosis of the femoral head with variable complications and resultant deformity of the femoral head and osteoarthritis. Suggested risk factors are acetabular retroversion, obesity, latitude, hyperactivity, and coagulopathy. The most commonly applied classification is based on radiolucency in the lateral pillar of the femoral head, which i...
متن کاملClinical Outcome of Femoral Osteotomy in Patients with Legg-Calve´-Perthes Disease
Background: Legg-Calve´-Perthes disease is a juvenile idiopathic osteonecrosis in which the blood supply of femoral head is not sufficient and the bone dies provisionally. The aim of this study is to evaluate outcome of Femoral osteotomy in children with LCPD in our University Hospital. Methods: In a descriptive analytic study, between 2008 and 2013, patients with the diagnosis of Legg-Calv...
متن کاملFate of the osteochondral fragments in osteochondritis dissecans after Legg-Calve-Perthes' disease.
The treatment of osteochondritis dissecans after Legg-Calvé-Perthes' disease has not been clearly determined. It may be either by simple observation or surgical removal of the osteochondral fragment. We studied the evolution of the lesion in 13 children and reviewed 92 hips reported in the literature. In our patients ten showed a tendency towards spontaneous healing, one required drilling + gra...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Journal of medical genetics
دوره 9 2 شماره
صفحات -
تاریخ انتشار 1972